THE 2-MINUTE RULE FOR ERLOSE

S1P receptor–mediated sensing of elevated S1P concentrations while in the blood and lymph serves being a standard system to bring about the egress of hematopoietic cells from tissues to the circulation (Determine 3). S1P1 expression on T and B cells stimulates their exit from lymphoid tissues, with reduced S1P levels, into blood or lymph, with su